doi: 10.1016/0309-1651(79)90097-3.
Affinity of human leukocyte interferon for polyribonucleotides
- PMID: 41640
- DOI: 10.1016/0309-1651(79)90097-3
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Affinity of human leukocyte interferon for polyribonucleotides
Cell Biol Int Rep.
1979 Nov.
Abstract
Human leukocyte interferon (HL-IF)binds to AGPOLY(A)TM, AGPOLY(U)TM and AGPOLY(I)TM. The bound interferon could be displaced from all three polyribonucleotides by including sodium chloride in the eluant. The nature of interaction of HL-IF with polyribonucleotides is electrostatic and not hydrophobic since its binding was not prevented in the presence of 50% ethylene glycol. The binding of HL-IF on AGPOLY(I)TM is stronger at lower pH since an increase in ionic strength is required to displace it.
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