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. 1979 Nov;3(8):663-9.
doi: 10.1016/0309-1651(79)90097-3.

Affinity of human leukocyte interferon for polyribonucleotides

K C Chadha, P M Grob

Affinity of human leukocyte interferon for polyribonucleotides

K C Chadha et al. Cell Biol Int Rep. 1979 Nov.

Abstract

Human leukocyte interferon (HL-IF)binds to AGPOLY(A)TM, AGPOLY(U)TM and AGPOLY(I)TM. The bound interferon could be displaced from all three polyribonucleotides by including sodium chloride in the eluant. The nature of interaction of HL-IF with polyribonucleotides is electrostatic and not hydrophobic since its binding was not prevented in the presence of 50% ethylene glycol. The binding of HL-IF on AGPOLY(I)TM is stronger at lower pH since an increase in ionic strength is required to displace it.

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