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Review
. 2026 Jan 20:6:1731949.
doi: 10.3389/froh.2025.1731949. eCollection 2025.

Beyond the clot: how the biomolecular landscape of platelet-rich fibrin directs fibroblast functions

Jiarui Bi  1 , Hannu Larjava  1 , Lari Häkkinen  1
Affiliations
Review

Beyond the clot: how the biomolecular landscape of platelet-rich fibrin directs fibroblast functions

Jiarui Bi et al. Front Oral Health. .

Abstract

Platelet-Rich Fibrin (PRF) is a second-generation autologous blood concentrate widely applied in regenerative medicine and dentistry for its wound-healing potential. Its clinical applications span dermatology, plastic surgery, periodontology, implantology, and oral maxillofacial surgery, with growing evidence supporting its effectiveness in tissue regeneration. Fibroblasts, as central regulators of extracellular matrix synthesis and remodeling, angiogenesis, and inflammation, are important targets of PRF's regenerative effects. This review summarizes the recent evidence of role of PRF in regulation of fibroblast functions important for wound healing and inflammation. It highlights PRF as a biologically active scaffold that accelerates soft tissue repair, primarily through modulation of fibroblasts, positioning it as a promising adjunct in regenerative therapies.

Keywords: PRF; fibroblast functions; inflammation; platelet-rich fibrin; regenerative therapies; soft tissue repair; wound healing.

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Conflict of interest statement

The author(s) declared that this work was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.

Figures

Figure 1
Figure 1
The graphical abstract of the effects of platelet-rich fibrin (PRF) on fibroblasts. Created in BioRender. Bi, J. (2026) https://BioRender.com/wjchht8
See this image and copyright information in PMC

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