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. 1978 Feb;15(2):267-72.
doi: 10.1016/0090-6980(78)90165-x.

Inhibition of prostaglandin biosynthesis by c-5,c-8,c-11-eicosatrienoic acid

W C van Evert, D H Nugteren, D A van Dorp

Inhibition of prostaglandin biosynthesis by c-5,c-8,c-11-eicosatrienoic acid

W C van Evert et al. Prostaglandins. 1978 Feb.

Abstract

The enzyme prostaglandin H leads to E-isomerase (EC 5.3.99.3), which is present in sheep vesicular gland and needs glutathione as cofactor, is inhibited by c-5,c-8,c-11-eicosatrienoic acid, the fatty acid accumulating during essential fatty acid deficiency. The EFA-deficiency syndrome can partly be explained from a prostaglandin deficiency caused by lack of precursors. The present finding indicates that 5,8,11-eicosatrienoic acid could well be an additional factor in modifying the symptoms of EFA-deficiency.

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