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Editorial
. 2026 Jan 31;18(1):46.
doi: 10.21037/jtd-2025-aw-2218. Epub 2026 Jan 20.

BID-ding wars: will dose-escalated twice daily radiotherapy for limited stage small cell lung cancer be the new standard of care?-critical analysis of the literature

Joseph A Miccio  1 , Nicholas J Potter  1 , Mitchell Machtay  1
Affiliations
Editorial

BID-ding wars: will dose-escalated twice daily radiotherapy for limited stage small cell lung cancer be the new standard of care?-critical analysis of the literature

Joseph A Miccio et al. J Thorac Dis. .
No abstract available

Keywords: Small cell lung cancer (SCLC); dose escalation; twice daily radiotherapy.

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Conflict of interest statement

Conflicts of Interest: All authors have completed the ICMJE uniform disclosure form (available at https://jtd.amegroups.com/article/view/10.21037/jtd-2025-aw-2218/coif). The authors have no conflicts of interest to declare.

Figures

Figure 1
Figure 1
Schematic of GTV, CTV, ITV, and PTV. CTV, clinical target volume; GTV, gross tumor volume; ITV, internal target volume; PTV, planning target volume.
Figure 2
Figure 2
PTV V100% and V95% in the standard and dose escalated arms of the Grønberg study. PTV, planning target volume.
See this image and copyright information in PMC

Comment on

References

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    1. Turrisi AT, 3rd, Kim K, Blum R, et al. Twice-daily compared with once-daily thoracic radiotherapy in limited small-cell lung cancer treated concurrently with cisplatin and etoposide. N Engl J Med 1999;340:265-71. 10.1056/NEJM199901283400403 - DOI - PubMed
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    1. Stahel RA, Ginsberg R, Havemann K, et al. Stahel, Rolf et al. Staging and prognostic factors in small cell lung cancer: a consensus report. Lung Cancer 1989;5:119-126.
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