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. 2026 Feb 9.
doi: 10.1186/s12967-026-07709-x. Online ahead of print.

Extracellular vesicles derived from astrocytes pretreated with melatonin promoted neuro-angiogenesis in mice with ischemic medial prefrontal cortex

Behnaz Mirzaahmadi  1   2 , Hajar Shafaie  3 , Javad Mahmoodi  4 , Parinaz Haddadi  5 , Ali Hassanzadeh  6 , Russel J Reiter  7 , Farzaneh Fazli  3   4 , Mohammad Karimipour #  8   9   10 , Reza Rahbarghazi #  11   12
Affiliations
Free article

Extracellular vesicles derived from astrocytes pretreated with melatonin promoted neuro-angiogenesis in mice with ischemic medial prefrontal cortex

Behnaz Mirzaahmadi et al. J Transl Med. .
Free article
No abstract available

Keywords: Astrocytes; Extracellular vesicle; Ischemic stroke; Melatonin; Neuro-angiogenesis.

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Conflict of interest statement

Declarations. Ethics approval and consent to participate: The study was registered as titled “The evaluation of the effect of melatonin-pretreated astrocyte-derived exosomes on neurogenesis and neural tissue regeneration in the medial”. All steps of this study were approved by the Ethical Committee of Tabriz University of Medical Sciences under the ethical code of (IR.TBZMED.AEC.1402.020) on 2023-05-29. Animals were treated according to the previously published ARRIVE guidelines. Consent for publication: Not applicable. Conflict of interest: None declared.

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