Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2026 Feb 11.
doi: 10.1186/s12974-026-03698-2. Online ahead of print.

APOE4 drives maladaptive heterogeneity and immunometabolic responses of astrocytes

Affiliations
Free article

APOE4 drives maladaptive heterogeneity and immunometabolic responses of astrocytes

Danielle S Goulding et al. J Neuroinflammation. .
Free article
No abstract available

Keywords: APOE; Astrocytes; Immunometabolism; Neuroinflammation.

PubMed Disclaimer

Conflict of interest statement

Declarations. Ethics approval and consent to participate: Not applicable. Consent for publication: Not applicable. Competing interests: The authors declare no competing interests.

Update of

References

    1. Holtzman DM, Herz J, Bu G. Apolipoprotein E and Apolipoprotein E receptors: normal biology and roles in alzheimer disease. Cold Spring Harb Perspect Med. 2012;2:a006312.
    1. Chung W-S, Clarke LE, Wang GX, Stafford BK, Sher A, Chakraborty C, Joung J, Foo LC, Thompson A, Chen C, et al. Astrocytes mediate synapse elimination through MEGF10 and MERTK pathways. Nature. 2013;504:394–400.
    1. Molofsky AV, Kelley KW, Tsai H-H, Redmond SA, Chang SM, Madireddy L, Chan JR, Baranzini SE, Ullian EM, Rowitch DH. Astrocyte-encoded positional cues maintain sensorimotor circuit integrity. Nature. 2014;509:189–94.
    1. Magistretti PJ. Neuron-glia metabolic coupling and plasticity. J Exp Biol. 2006;209:2304–11.
    1. Bennett FC, Molofsky AV. The immune system and psychiatric disease: a basic science perspective. Clin Exp Immunol. 2019;197:294–307.

LinkOut - more resources