Precision targeting of CCNE1-amplified tumors-lessons from BLU-222 and beyond
- PMID: 41674953
- PMCID: PMC12885798
- DOI: 10.21037/tcr-2025-2105
Precision targeting of CCNE1-amplified tumors-lessons from BLU-222 and beyond
Keywords: BLU-222; CCNE1; cyclin-dependent kinase 2 inhibitor (CDK2 inhibitor); ovarian cancer.
Conflict of interest statement
Conflicts of Interest: Both authors have completed the ICMJE uniform disclosure form (available at https://tcr.amegroups.com/article/view/10.21037/tcr-2025-2105/coif). D.U. reports that this work was supported by the Research Council of Finland (Profi6 #336449, #333583, #360437, the Sigrid Jusélius Foundation, and the Cancer Foundation Finland. The other author has no conflicts of interest to declare.
Comment on
-
Profiling the Activity of the Potent and Highly Selective CDK2 Inhibitor BLU-222 Reveals Determinants of Response in CCNE1-Aberrant Ovarian and Endometrial Tumors.Cancer Res. 2025 Apr 3;85(7):1297-1309. doi: 10.1158/0008-5472.CAN-24-2360. Cancer Res. 2025. PMID: 39945650 Free PMC article.
References
-
- Yap TA, Elhaddad AM, Grisham RN, et al. First-in-human phase 1/2a study of a potent and novel CDK2-selective inhibitor PF-07104091 in patients (pts) with advanced solid tumors, enriched for CDK4/6 inhibitor resistant HR+/HER2- breast cancer. J Clin Oncol 2023;41:3010. 10.1200/JCO.2023.41.16_suppl.3010 - DOI
-
- Dietrich C, Trub A, Ahn A, et al. INX-315, a Selective CDK2 Inhibitor, Induces Cell Cycle Arrest and Senescence in Solid Tumors. Cancer Discov 2024;14:446-67. 10.1158/2159-8290.CD-23-0954 - DOI - PMC - PubMed
Publication types
LinkOut - more resources
Full Text Sources
Miscellaneous