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Editorial
. 2026 Jan 31;15(1):4.
doi: 10.21037/tcr-2025-2105. Epub 2026 Jan 20.

Precision targeting of CCNE1-amplified tumors-lessons from BLU-222 and beyond

Affiliations
Editorial

Precision targeting of CCNE1-amplified tumors-lessons from BLU-222 and beyond

Frida Rantanen et al. Transl Cancer Res. .
No abstract available

Keywords: BLU-222; CCNE1; cyclin-dependent kinase 2 inhibitor (CDK2 inhibitor); ovarian cancer.

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Conflict of interest statement

Conflicts of Interest: Both authors have completed the ICMJE uniform disclosure form (available at https://tcr.amegroups.com/article/view/10.21037/tcr-2025-2105/coif). D.U. reports that this work was supported by the Research Council of Finland (Profi6 #336449, #333583, #360437, the Sigrid Jusélius Foundation, and the Cancer Foundation Finland. The other author has no conflicts of interest to declare.

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References

    1. Yang L, Xie HJ, Li YY, et al. Molecular mechanisms of platinum‑based chemotherapy resistance in ovarian cancer (Review). Oncol Rep 2022;47:82. 10.3892/or.2022.8293 - DOI - PMC - PubMed
    1. Rubinstein M, Shen S, Monk BJ, et al. Looking beyond carboplatin and paclitaxel for the treatment of advanced/recurrent endometrial cancer. Gynecol Oncol 2022;167:540-6. 10.1016/j.ygyno.2022.10.012 - DOI - PMC - PubMed
    1. Gorski JW, Ueland FR, Kolesar JM. CCNE1 Amplification as a Predictive Biomarker of Chemotherapy Resistance in Epithelial Ovarian Cancer. Diagnostics (Basel) 2020;10:279. 10.3390/diagnostics10050279 - DOI - PMC - PubMed
    1. Yap TA, Elhaddad AM, Grisham RN, et al. First-in-human phase 1/2a study of a potent and novel CDK2-selective inhibitor PF-07104091 in patients (pts) with advanced solid tumors, enriched for CDK4/6 inhibitor resistant HR+/HER2- breast cancer. J Clin Oncol 2023;41:3010. 10.1200/JCO.2023.41.16_suppl.3010 - DOI
    1. Dietrich C, Trub A, Ahn A, et al. INX-315, a Selective CDK2 Inhibitor, Induces Cell Cycle Arrest and Senescence in Solid Tumors. Cancer Discov 2024;14:446-67. 10.1158/2159-8290.CD-23-0954 - DOI - PMC - PubMed

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