Evidence for the independence of human immunoglobulin class levels

Abstract

Rank correlation analysis of serum IgG, IgA and IgM values from a large group of subjects showed that in health the amount of one class of immunoglobulin present in an individual is largely independent of the amounts of the other classes. A similar analysis of several sets of data from the literature concerning immunoglobulin levels in disease showed that even with severe disturbances of the immunoglobulin system, the levels remained independent.