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Comment
. 2026 Jan 27;22(4):2121-2123.
doi: 10.7150/ijbs.129515. eCollection 2026.

Spatial Pharmacology: Redefining Organelle Contact Sites as Therapeutic Targets

Minjeong Ko  1 , Jiho You  1 , Eunwoo Cho  1 , Ho Jeong Kwon  1
Affiliations
Comment

Spatial Pharmacology: Redefining Organelle Contact Sites as Therapeutic Targets

Minjeong Ko et al. Int J Biol Sci. .
No abstract available

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Conflict of interest statement

Competing Interests: The authors have declared that no competing interest exists.

Figures

Figure 1
Figure 1
Translating organelle contact site biology into spatial pharmacology and therapeutic intervention. Understanding of organelle membrane contact sites (MCSs) has progressed from structural characterization to therapeutic exploration. Small molecules and peptides that modulate ER-mitochondria or ER-lysosome contact dynamics can reprogram inter-organelle signaling and metabolic coordination, offering new opportunities for therapeutic intervention in neurodegenerative, cancer, and metabolic disorders.
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Comment on

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