Long non-coding RNA H19 transported by colorectal cancer small extracellular vesicles promotes alternative splicing in healthy hepatocytes: new insights on liver pre-metastatic niche formation

Marco Loria^{1

2}, Denise Anello¹, Aurora Cordaro¹, Chiara Zichittella¹, Simona Fontana¹, Riccardo Alessandro^{1

3}, Alice Conigliaro^{4

5}

Affiliations

¹ Department of Biomedicine Neuroscience and Advanced Diagnostic (Bi.N.D.), University of Palermo, Section of Biology and Genetics, Palermo, 90133, Italy.
² Department of Molecular Medicine, Sapienza University of Rome, Rome, Italy.
³ Institute for Biomedical Research and Innovation (IRIB), National Research Council (CNR), Palermo, Italy.
⁴ Department of Biomedicine Neuroscience and Advanced Diagnostic (Bi.N.D.), University of Palermo, Section of Biology and Genetics, Palermo, 90133, Italy. alice.conigliaro@unipa.it.
⁵ ATeN Center - Advanced Technologies Network Center, University of Palermo, Palermo, Italy. alice.conigliaro@unipa.it.

Free article

Marco Loria et al. Cell Commun Signal. 2026.

Free article

. 2026 Feb 17.

doi: 10.1186/s12964-026-02738-x. Online ahead of print.

Marco Loria^{1

2}, Denise Anello¹, Aurora Cordaro¹, Chiara Zichittella¹, Simona Fontana¹, Riccardo Alessandro^{1

3}, Alice Conigliaro^{4

5}

¹ Department of Biomedicine Neuroscience and Advanced Diagnostic (Bi.N.D.), University of Palermo, Section of Biology and Genetics, Palermo, 90133, Italy.
² Department of Molecular Medicine, Sapienza University of Rome, Rome, Italy.
³ Institute for Biomedical Research and Innovation (IRIB), National Research Council (CNR), Palermo, Italy.
⁴ Department of Biomedicine Neuroscience and Advanced Diagnostic (Bi.N.D.), University of Palermo, Section of Biology and Genetics, Palermo, 90133, Italy. alice.conigliaro@unipa.it.
⁵ ATeN Center - Advanced Technologies Network Center, University of Palermo, Palermo, Italy. alice.conigliaro@unipa.it.

No abstract available

Keywords: Alternative splicing; Colorectal cancer; Extracellular vesicles; Non-coding RNA.

Conflict of interest statement

Declarations. Competing interests: The authors declare no competing interests.

1. Marabti EE, Younis I. The cancer spliceome: reprograming of alternative splicing in cancer. Front Media SA. 2018. https://doi.org/10.3389/fmolb.2018.00080.
1. Bonner EA, Lee SC. Therapeutic Targeting of RNA Splicing in Cancer. Multidisciplinary Digital Publishing Institute (MDPI). 2023. https://doi.org/10.3390/genes14071378.
1. Zhang Y, Qian J, Gu C, Yang Y. Alternative splicing and cancer: a systematic review. Springer Nature; 2021. https://doi.org/10.1038/s41392-021-00486-7.
1. Liu Z, Rabadan R. Computing the Role of Alternative Splicing in Cancer. Cell Press. 2021. https://doi.org/10.1016/j.trecan.2020.12.015.
1. Xiong Y, et al Profiles of alternative splicing in colorectal cancer and their clinical significance: A study based on large-scale sequencing data. EBioMedicine. 2018;36:183–95. https://doi.org/10.1016/j.ebiom.2018.09.021.