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Review
. 2026 Feb 14;97(12):1037-1043.
doi: 10.26442/00403660.2025.12.203481.

[Probiotics' position in clinical practice: focus on the combination of Lactobacillus acidophilus (LA-5) and Bifidobacterium animalis subsp. lactis (BB-12). A review]

[Article in Russian]
Affiliations
Review

[Probiotics' position in clinical practice: focus on the combination of Lactobacillus acidophilus (LA-5) and Bifidobacterium animalis subsp. lactis (BB-12). A review]

[Article in Russian]
A V Gorelov et al. Ter Arkh. .

Abstract

Probiotics are currently widely used in clinical practice to prevent and treat a wide range of diseases. The purpose of our review is to highlight what we consider to be the most significant clinical studies on the use of probiotics for preventing antibiotic-associated diarrhea, clostridial diarrhea and pseudomembranous colitis. The article also presents the results of studies confirming the efficacy of probiotics in Helicobacter pylori eradication therapy. The review focuses on Linex® Forte, medicinal product containing the combination of Lactobacillus acidophilus (LA-5) and Bifidobacterium animalis subsp. lactis (BB-12).

В настоящее время пробиотики широко применяются в клинической практике для профилактики и лечения большого количества заболеваний. Цель нашего обзора – осветить наиболее значимые, на наш взгляд, клинические исследования, касающиеся применения пробиотиков для профилактики антибиотик-ассоциированной диареи, клостридиальной диареи и псевдомембранозного колита. Также в статье приведены результаты исследований, подтверждающих эффективность пробиотиков при эрадикационной терапии Helicobacter pylori. Особое внимание в обзоре уделено лекарственному препарату Линекс® Форте, содержащему в своем составе комбинацию пробиотических бактерий Lactobacillus acidophilus (LA-5) и Bifidobacterium animalis subsp. lactis (BB-12).

Keywords: Bifidobacterium; Lactobacillus; gastrointestinal tract; microbiome; microflora; probiotics.

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