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. 2026 Feb 19.
doi: 10.1186/s12864-026-12650-w. Online ahead of print.

Multi-omics insights into gut microbiota-metabolite interactions under probiotic intervention in a developmental cafeteria diet model

Taha Ceylani  1   2 , Hikmet Taner Teker  3 , Harun Önlü  4   5 , Turgay Ünver  6 , Hüseyin Allahverdi  5 , Emre Şahin  7   8 , Ekrem Atalan  9
Affiliations
Free article

Multi-omics insights into gut microbiota-metabolite interactions under probiotic intervention in a developmental cafeteria diet model

Taha Ceylani et al. BMC Genomics. .
Free article
No abstract available

Keywords: Cafeteria diet; Development period; Gut microbiota; Metagenomics; SCD probiotics; SCFAs; Shotgun sequencing.

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Conflict of interest statement

Declarations. Ethics approval and consent to participate: This study was carried out with the approval of the Ethics Committee (meeting date: 29.06.2021, approval number: 2021/03) from the Bingöl University Animal Experiments Local Ethics Committee. Consent for publication: Not applicable. Competing interests: The authors declare no competing interests.

References

    1. Ceylani T, Jakubowska-Doğru E, Gurbanov R, Teker HT, Gozen AG. The effects of repeated antibiotic administration to juvenile BALB/c mice on the microbiota status and animal behavior at the adult age. Heliyon. 2018;4:e00644. https://doi.org/10.1016/j.heliyon.2018.e00644.
    1. Lalanza JF, Caimari A, del Bas JM, Torregrosa D, Cigarroa I, Pallàs M, et al. Effects of a post-weaning cafeteria diet in young rats: metabolic syndrome, reduced activity and low anxiety-like behaviour. PLoS ONE. 2014;9:e85049. https://doi.org/10.1371/journal.pone.0085049.
    1. Sampey BP, Vanhoose AM, Winfield HM, Freemerman AJ, Muehlbauer MJ, Fueger PT, et al. Cafeteria diet is a robust model of human metabolic syndrome with liver and adipose inflammation: comparison to high-fat diet. Obes (Silver Spring). 2011;19:1109–17. https://doi.org/10.1038/oby.2011.18.
    1. Ceylani T, Önlü H, Keskin S, Allahverdi H, Teker HT. SCD probiotics mitigate cafeteria diet-induced liver damage in Wistar rats during development. J Gastroenterol Hepatol. 2023;38:2142–51. https://doi.org/10.1111/jgh.16395.
    1. Aba N, Koçpınar EF, Ceylani T. The hepatic antioxidant system damage induced with the cafeteria (CAF) diet is largely counteracted using SCD probiotics during development of male Wistar rats. Nutrients. 2023;15. https://doi.org/10.3390/nu15214557.

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