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. 2026 Feb 21.
doi: 10.1007/s12010-026-05599-9. Online ahead of print.

Erythropoietin and Ferulic Acid Loaded on Fe3O4 Nanoparticles Exert Therapeutic Effect against Acute Kidney Injury Induced by Cisplatin Via Bcl-2/Bax, IL-6, TGF-β, and GPX-4 Mechanisms

Lamiaa A A Barakat #  1 , Aya Ashour Aref #  1 , Salma M Khirallah  2   3
Affiliations

Erythropoietin and Ferulic Acid Loaded on Fe3O4 Nanoparticles Exert Therapeutic Effect against Acute Kidney Injury Induced by Cisplatin Via Bcl-2/Bax, IL-6, TGF-β, and GPX-4 Mechanisms

Lamiaa A A Barakat et al. Appl Biochem Biotechnol. .
No abstract available

Keywords: Cisplatin; Erythropoietin; Fe3O4-NPs; Ferulic acid.

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Conflict of interest statement

Declarations. Ethical Approval: The ARRIVE criteria and the guidelines established by the National Research Council for the care and utilization of laboratory animals were adhered to in all experimental procedures. It was approved by the Port Said University Faculty of Science’s research ethics committee (ERN: PSU.Sci.1). Clinical Trial Number: Not applicable. Conflict of interest: The authors declare that they have no conflict of interest.

References

    1. Fang, C., Lou, D., yong, Zhou, L., qin, Wang, J., Yang, B., & He, Q. (2021). Natural products: Potential treatments for cisplatin-induced nephrotoxicity. Acta Pharmacologica Sinica, 42(12), 1951–1969. - DOI
    1. Mapuskar, K. A., Pulliam, C. F., Zepeda-Orozco, D., Griffin, B. R., Furqan, M., Spitz, D. R. Redox Regulation of Nrf2 in Cisplatin-Induced Kidney Injury. Antioxidants. 2023 Sept 6;12(9):1728.
    1. McSweeney, K. R., Gadanec, L. K., Qaradakhi, T., Ali, B. A., Zulli, A., & Apostolopoulos, V. (2021). Mechanisms of Cisplatin-Induced acute kidney injury: Pathological Mechanisms, Pharmacological Interventions, and genetic mitigations. Cancers, 13(7), 1572. - DOI
    1. Motwani, S. S., Sandhu, S. K., & Kitchlu, A. (2022). Cisplatin nephrotoxicity: Novel insights into mechanisms and preventative strategies. Seminars in Nephrology, 42(6), 151341. - DOI
    1. Moradi, Z., Maali, A., Shad, J. S., Farasat, A., Kouchaki, R., Moghadami, M., et al. (2020). Updates on novel Erythropoiesis-Stimulating agents: Clinical and molecular approach. Indian J Hematol Blood Transfus, 36(1), 26–36. - DOI

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