Synthesis and biological evaluation of 6-hydroxychromone based thiosemicarbazones as potential antidiabetic and antioxidant agents

Affiliations

¹ Institute of Chemical Sciences, Bahauddin Zakariya University, 60800, Multan, Pakistan.
² College of Chemistry & Chemical Engineering, Central South University, Changsha, 410083, Hunan, China.
³ Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Bahauddin Zakariya University, Multan, 60800, Pakistan.
⁴ Department of Biotechnology, Faculty of Science, Bartin University, 74110, Bartin, Turkey.
⁵ Department of Chemistry, Forman Christian College (A Chartered University), Ferozepur Road 54600, Lahore, Pakistan.
⁶ Department of Chemistry, Faculty of Science, Research Center for Advanced Materials Science (RCAMS), King Khalid University, P.O. Box 960, Abha, 61421, Saudi Arabia.
⁷ Department of Chemistry, Faculty of Science, Imam Mohammad Ibn Saud Islamic University (IMSIU), Riyadh, 11623, Saudi Arabia.
⁸ Department of Chemistry, Faculty of Science, Islamic University of Madinah, Madinah, 42351, Saudi Arabia. smgomha@iu.edu.sa.
⁹ Department of Chemistry, Rabigh Branch, Science & Arts College, King Abdulaziz University, Rabigh, 21911, Saudi Arabia.
¹⁰ Institute of Chemical Sciences, Bahauddin Zakariya University, 60800, Multan, Pakistan. zahidshafiq@bzu.edu.pk.

Free article

Wajeeha Zareen et al. Sci Rep. 2026.

Free article

. 2026 Feb 22;16(1):7512.

doi: 10.1038/s41598-026-40449-y.

¹ Institute of Chemical Sciences, Bahauddin Zakariya University, 60800, Multan, Pakistan.
² College of Chemistry & Chemical Engineering, Central South University, Changsha, 410083, Hunan, China.
³ Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Bahauddin Zakariya University, Multan, 60800, Pakistan.
⁴ Department of Biotechnology, Faculty of Science, Bartin University, 74110, Bartin, Turkey.
⁵ Department of Chemistry, Forman Christian College (A Chartered University), Ferozepur Road 54600, Lahore, Pakistan.
⁶ Department of Chemistry, Faculty of Science, Research Center for Advanced Materials Science (RCAMS), King Khalid University, P.O. Box 960, Abha, 61421, Saudi Arabia.
⁷ Department of Chemistry, Faculty of Science, Imam Mohammad Ibn Saud Islamic University (IMSIU), Riyadh, 11623, Saudi Arabia.
⁸ Department of Chemistry, Faculty of Science, Islamic University of Madinah, Madinah, 42351, Saudi Arabia. smgomha@iu.edu.sa.
⁹ Department of Chemistry, Rabigh Branch, Science & Arts College, King Abdulaziz University, Rabigh, 21911, Saudi Arabia.
¹⁰ Institute of Chemical Sciences, Bahauddin Zakariya University, 60800, Multan, Pakistan. zahidshafiq@bzu.edu.pk.

No abstract available

Keywords: 6-Hydroxychromone; Antidiabetic; Antioxidant; Enzyme inhibition; Molecular docking; Thiosemicarbazones.

Conflict of interest statement

Declarations. Competing interests: The authors declare no competing interests.

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