Impact of ambient particulate matter and meteorological factors on COPD risk and its association with blood eosinophilia

Amja Manullang^#¹, Xuan Ngoc Tran^#¹, Yueh-Lun Lee^#², Yuan-Hung Wang^{3

4}, Yuan-Chien Lin⁵, Kang-Yun Lee^{6

7}, Chi-Li Chung^{8

9}, Tzu-Tao Chen^{6

7}, Kuan-Yuan Chen^{6

7}, Chien-Hua Tseng^{6

7

10}, Chien-Ling Su⁷, Shu-Chuan Ho^{7

8}, Feng-Ming Yang¹¹, Sheng-Ming Wu^{6

7}, Kian Fan Chung¹², Kai-Jen Chuang^{13

14}, Jer-Hwa Chang^{15

16}, Hsiao-Chi Chuang^{17

18

19}

Affiliations

¹ International Ph.D. Program in Medicine, College of Medicine, Taipei Medical University, Taipei, Taiwan.
² Department of Microbiology and Immunology, School of Medicine, College of Medicine, Taipei Medical University, Taipei, Taiwan.
³ Graduate Institute of Clinical Medicine, College of Medicine, Taipei Medical University, Taipei, Taiwan.
⁴ Department of Medical Research, Shuang Ho Hospital, Taipei Medical University, New Taipei City, Taiwan.
⁵ Department of Civil Engineering, National Central University, Taoyuan City, Taiwan.
⁶ Division of Pulmonary Medicine, Department of Internal Medicine, School of Medicine, College of Medicine, Taipei Medical University, Taipei, Taiwan.
⁷ Division of Pulmonary Medicine, Department of Internal Medicine, Shuang Ho Hospital, Taipei Medical University, New Taipei City, Taiwan.
⁸ School of Respiratory Therapy, College of Medicine, Taipei Medical University, Taipei, Taiwan.
⁹ Division of Pulmonary Medicine, Department of Internal Medicine, Taipei Medical University Hospital, Taipei Medical University, Taipei, Taiwan.
¹⁰ Division of Critical Care Medicine, Department of Emergency and Critical Care Medicine, Shuang Ho Hospital, Taipei Medical University, New Taipei City, Taiwan.
¹¹ Graduate Institute of Physiology, College of Medicine, National Taiwan University, Taipei, Taiwan.
¹² National Heart & Lung Institute, Imperial College London, London, UK.
¹³ School of Public Health, College of Public Health, Taipei Medical University, Taipei, Taiwan.
¹⁴ Department of Public Health, School of Medicine, College of Medicine, Taipei Medical University, Taipei, Taiwan.
¹⁵ School of Respiratory Therapy, College of Medicine, Taipei Medical University, Taipei, Taiwan. jerhwa@tmu.edu.tw.
¹⁶ Division of Pulmonary Medicine, Department of Internal Medicine, Wan Fang Hospital, Taipei Medical University, Taipei, Taiwan. jerhwa@tmu.edu.tw.
¹⁷ Division of Pulmonary Medicine, Department of Internal Medicine, Shuang Ho Hospital, Taipei Medical University, New Taipei City, Taiwan. chuanghc@tmu.edu.tw.
¹⁸ School of Respiratory Therapy, College of Medicine, Taipei Medical University, Taipei, Taiwan. chuanghc@tmu.edu.tw.
¹⁹ Cell Physiology and Molecular Image Research Center, Wan Fang Hospital, Taipei Medical University, Taipei, Taiwan. chuanghc@tmu.edu.tw.

^# Contributed equally.

PMID: 41731422
DOI: 10.1186/s12890-026-04168-4

Free article

Impact of ambient particulate matter and meteorological factors on COPD risk and its association with blood eosinophilia

Amja Manullang et al. BMC Pulm Med. 2026.

Free article

. 2026 Feb 23.

doi: 10.1186/s12890-026-04168-4. Online ahead of print.

Authors

Affiliations

¹ International Ph.D. Program in Medicine, College of Medicine, Taipei Medical University, Taipei, Taiwan.
² Department of Microbiology and Immunology, School of Medicine, College of Medicine, Taipei Medical University, Taipei, Taiwan.
³ Graduate Institute of Clinical Medicine, College of Medicine, Taipei Medical University, Taipei, Taiwan.
⁴ Department of Medical Research, Shuang Ho Hospital, Taipei Medical University, New Taipei City, Taiwan.
⁵ Department of Civil Engineering, National Central University, Taoyuan City, Taiwan.
⁶ Division of Pulmonary Medicine, Department of Internal Medicine, School of Medicine, College of Medicine, Taipei Medical University, Taipei, Taiwan.
⁷ Division of Pulmonary Medicine, Department of Internal Medicine, Shuang Ho Hospital, Taipei Medical University, New Taipei City, Taiwan.
⁸ School of Respiratory Therapy, College of Medicine, Taipei Medical University, Taipei, Taiwan.
⁹ Division of Pulmonary Medicine, Department of Internal Medicine, Taipei Medical University Hospital, Taipei Medical University, Taipei, Taiwan.
¹⁰ Division of Critical Care Medicine, Department of Emergency and Critical Care Medicine, Shuang Ho Hospital, Taipei Medical University, New Taipei City, Taiwan.
¹¹ Graduate Institute of Physiology, College of Medicine, National Taiwan University, Taipei, Taiwan.
¹² National Heart & Lung Institute, Imperial College London, London, UK.
¹³ School of Public Health, College of Public Health, Taipei Medical University, Taipei, Taiwan.
¹⁴ Department of Public Health, School of Medicine, College of Medicine, Taipei Medical University, Taipei, Taiwan.
¹⁵ School of Respiratory Therapy, College of Medicine, Taipei Medical University, Taipei, Taiwan. jerhwa@tmu.edu.tw.
¹⁶ Division of Pulmonary Medicine, Department of Internal Medicine, Wan Fang Hospital, Taipei Medical University, Taipei, Taiwan. jerhwa@tmu.edu.tw.
¹⁷ Division of Pulmonary Medicine, Department of Internal Medicine, Shuang Ho Hospital, Taipei Medical University, New Taipei City, Taiwan. chuanghc@tmu.edu.tw.
¹⁸ School of Respiratory Therapy, College of Medicine, Taipei Medical University, Taipei, Taiwan. chuanghc@tmu.edu.tw.
¹⁹ Cell Physiology and Molecular Image Research Center, Wan Fang Hospital, Taipei Medical University, Taipei, Taiwan. chuanghc@tmu.edu.tw.

^# Contributed equally.

PMID: 41731422
DOI: 10.1186/s12890-026-04168-4

No abstract available

Keywords: Air pollution; COPD; Particulate matter; Relative humidity; Temperature.

PubMed Disclaimer

Conflict of interest statement

Declarations. Ethics approval and consent to participate: The study was conducted in accordance with the Declaration of Helsinki and was approved by the Taipei Medical University-Joint Institutional Review Board (TMU-JIRB no. N202003075) approved this study. Given the retrospective design, the requirement for informed consent was waived because all procedures were part of routine clinical care. Consent for publication: Not applicable. Competing interests: The authors declare no competing interests.

References

1. Dockery DW, Pope CA 3rd, Xu X, Spengler JD, Ware JH, Fay ME, et al. An association between air pollution and mortality in six U.S. Cities. N Engl J Med. 1993;329(24):1753–9.
1. Atkinson RW, Anderson HR, Sunyer J, Ayres J, Baccini M, Vonk JM, et al. Acute effects of particulate air pollution on respiratory admissions: results from APHEA 2 project. Air pollution and health: a European approach. Am J Respir Crit Care Med. 2001;164(10 Pt 1):1860–6.
1. Hooper LG, Young MT, Keller JP, Szpiro AA, O’Brien KM, Sandler DP, et al. Ambient air pollution and chronic bronchitis in a cohort of U.S. Women. Environ Health Perspect. 2018;126(2):027005.
1. Yan P, Liu P, Lin R, Xiao K, Xie S, Wang K, et al. Effect of ambient air quality on exacerbation of COPD in patients and its potential mechanism. Int J Chronic Obstr Pulm Dis. 2019;14:1517–26.
1. Liu S, Zhou Y, Liu S, Chen X, Zou W, Zhao D, et al. Association between exposure to ambient particulate matter and chronic obstructive pulmonary disease: results from a cross-sectional study in China. Thorax. 2017;72(9):788–95.

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Impact of ambient particulate matter and meteorological factors on COPD risk and its association with blood eosinophilia

Affiliations

Impact of ambient particulate matter and meteorological factors on COPD risk and its association with blood eosinophilia

Authors

Affiliations

Conflict of interest statement

References

Grants and funding

LinkOut - more resources

Full Text Sources