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. 2026 Feb 11;14(2):103.
doi: 10.3390/dj14020103.

Combining Hyaluronic Acid and Amino Acids for Improved Healing of Post-Extraction Tooth Socket in Type 2 Diabetes Mellitus Subjects: A Randomized Clinical Trial

Tiziana Ruggiero  1 , Davide Camisassa  1 , Marta Bezzi  1   2 , Ettore Cogno  1 , Benedetta Brugiafreddo  1 , Vincenzo Nobile  3 , Renato Pol  1 , Ilaria Roato  1 , Federico Mussano  1 , Paolo Giacomo Arduino  1
Affiliations

Combining Hyaluronic Acid and Amino Acids for Improved Healing of Post-Extraction Tooth Socket in Type 2 Diabetes Mellitus Subjects: A Randomized Clinical Trial

Tiziana Ruggiero et al. Dent J (Basel). .

Abstract

Background/Objectives: Conventional wound care often fails to address the complex pathology of diabetic wounds adequately. Research shows that hyaluronic acid and its derivatives promote tissue regeneration in the later stages of wound healing. We evaluated the efficacy of a novel topical formulation in promoting socket healing following post-extraction in patients with type-2 diabetes mellitus, by combining sodium hyaluronate and six amino acids involved in collagen synthesis. Methods: A single-center, two-arm randomized controlled trial was conducted in adults aged 18 and over with type 2 diabetes requiring extraction of at least one non-impacted tooth. Forty-four participants were randomized to receive either the intervention or no treatment. Primary outcomes included a modified Landry's healing index and rate of socket closure. Results: Comparative analysis showed significantly improved healing index scores in the intervention group by day 7 and day 14 compared to control, with no improvements in the rate of socket closure. Conclusions: This research provides evidence on the therapeutic efficacy of the gel formulation under study in promoting wound healing of post-extraction sites in diabetic patients undergoing tooth extraction. Further research is needed to compare its efficacy with standard treatments and adjunct therapies.

Keywords: amino acid; healing; hyaluronic acid; tooth extraction; tooth socket; type-2 diabetes mellitus.

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Conflict of interest statement

Author Vincenzo Nobile was employed by the company Complife Italia S.r.l. The remaining authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.

Figures

Figure 1
Figure 1
CONSORT 2025 Flow Diagram. Flow diagram of the progress through the phases of a randomized trial of two groups (that is, enrolment, intervention allocation, follow-up, and data analysis).
Figure 2
Figure 2
Images depicting linear measurements, expressed in millimeters, the maximum oral-vestibule OV diameter (A), the maximum mesiodistal MD diameter (B), and the maximum socket depth P (C).
See this image and copyright information in PMC

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