[Comparative study of the action of carcinogenic substances that induce transplacental blastomogenesis in rabbits]

Abstract

The injection of blastomogenic agents--ENM, MNM, DMBA and BP in rabbits during the last third of the pregnancy period would induce in their offspring tumors mostly of peripheral nerves and kidney. Ethylnitrosourea shows the highest blastomogenic activity in rabbits than other carcinogens; it also exhibits a rather pronounced neurotropic blastomogenic effect. Relative tropism to different organs and tissues characteristic of carcinogens in their effect on the adult organism is not always manifested in transplacental blastomogenesis. Transplacental tumors induced in rabbits are of special importance, since thus the model of a neoplasm, most frequently observed in children, may be obtained.