How to build a testis, cell by cell

Rod T Mitchell^{1

2}

Affiliations

¹ Department of Paediatric Endocrinology, Royal Hospital for Children and Young People, Edinburgh, UK.
² Centre for Reproductive Health, Institute for Regeneration and Repair, University of Edinburgh, Edinburgh, UK.

Comment

Rod T Mitchell. Science. 2026.

. 2026 Feb 26;391(6788):865-866.

doi: 10.1126/science.aef2220. Epub 2026 Feb 26.

Rod T Mitchell^{1

2}

¹ Department of Paediatric Endocrinology, Royal Hospital for Children and Young People, Edinburgh, UK.
² Centre for Reproductive Health, Institute for Regeneration and Repair, University of Edinburgh, Edinburgh, UK.

Abstract

Engineered pluripotent stem cells form somatic and germ cells that mimic a functional testis.

Reconstitution of sex determination and the testicular niche using mouse pluripotent stem cells.
Yoshino T, Sasada H, Sato T, Nakamura T, Shirane K, Ohta H, Kamoshita M, Inoue M, Matsudaira Y, Liu C, Matsufuji M, Tachibana M, Morohashi KI, Ikawa M, Saitou M, Ogawa T, Hayashi K. Yoshino T, et al. Science. 2026 Feb 26;391(6788):eaea0296. doi: 10.1126/science.aea0296. Epub 2026 Feb 26. Science. 2026. PMID: 41747038