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. 1968 Nov 1;128(5):1049-57.
doi: 10.1084/jem.128.5.1049.

Interactions of the complement system with endotoxic lipopolysaccharide: consumption of each of the six terminal complement components

H Gewurz, H S Shin, S E Mergenhagen

Interactions of the complement system with endotoxic lipopolysaccharide: consumption of each of the six terminal complement components

H Gewurz et al. J Exp Med. .

Abstract

Large amounts of each C'3, C'5, C'6, C'7, C'8, and C'9 were consumed when guinea pig serum was incubated with endotoxic lipopolysaccharide, zymosan, or preformed immune complexes. Since these C' components subserve several of the biological activities which follow the injection of endotoxins into experimental animals, these experiments support the hypothesis that certain biological effects induced by endotoxins may be mediated via the C' system, and may account for some of the known similarity in the reactivities evoked by endotoxins and immune complexes in vivo.

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References

    1. J Exp Med. 1967 Feb 1;125(2):359-80 - PubMed
    1. Science. 1954 Aug 20;120(3112):279-85 - PubMed
    1. J Immunol. 1963 Dec;91:748-56 - PubMed
    1. Immunochemistry. 1966 Mar;3(2):111-35 - PubMed
    1. J Ultrastruct Res. 1967 Jul;19(1):45-83 - PubMed