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. 2026 Feb 28.
doi: 10.1186/s12943-026-02617-6. Online ahead of print.

Integrated single-cell and spatial transcriptomic profiling decodes lineage plasticity and immune microenvironment remodeling in prostate cancer progression

Hongyuan Yu #  1 , Yusong Wang #  2 , Mingcong He #  3 , Yiming Chen  1 , Jianbin Bi  4 , Xuyong Lin  5 , Xiaolu Cui  6
Affiliations
Free article

Integrated single-cell and spatial transcriptomic profiling decodes lineage plasticity and immune microenvironment remodeling in prostate cancer progression

Hongyuan Yu et al. Mol Cancer. .
Free article
No abstract available

Keywords: Lineage plasticity; Prostate cancer; Single-cell RNA sequencing; Spatial transcriptomics; Treatment resistance; Tumor microenvironment.

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Conflict of interest statement

Declarations. Ethics approval and consent to participate: All procedures involving human participants in this study were conducted in accordance with the ethical standards of the China Medical University Institutional Review Board (approval number: AF-SOP-07-1.201) and with the 1964 Helsinki declaration and its later amendments. Informed consent was obtained from all individual participants included in thes study. All animal experiments were approved by the China Medical University Animal Care and Use Committee (approval number: CMU20241328) and were performed in accordance with the institutional guidelines for the care and use of laboratory animals. All procedures involving animals complied with the ARRIVE guidelines and were conducted in accordance with the U.K. Animals (Scientific Procedures) Act, 1986 and associated guidelines, EU Directive 2010/63/EU for animal experiments. Competing interests: The authors declare no competing interests.

References

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