Genetic implications of common region sequence comparisons of lambda immunoglobulin chains differing at position 190

Abstract

The common regions of two lambda chains (amino acid residues 109 to 213) have been partially sequenced. These two human immunoglobulin chains have lysine at position 190, but are otherwise identical in their common-region sequence to four reported lambda chains that have arginine at position 190. The single amino acid interchange at position 190 may be explained either by an ambiguous codon at this position or by a gene duplication so recent that only a single mutational event has occured.