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. 1978 Mar 1;169(3):697-701.
doi: 10.1042/bj1690697.

Demineralization in organic solvents by alkylammonium salts of ethylenediaminetetra-acetic acid

J E Scott, T W Kyffin

Demineralization in organic solvents by alkylammonium salts of ethylenediaminetetra-acetic acid

J E Scott et al. Biochem J. .

Abstract

1. Insoluble salts of alklaine earth metals (e. g. calcium phosphate) dissolve in non-aqueous solvents containing EDTA salts of organic cations (e.g. tetraethylammonium). 2. Bone is efficiently demineralized in ethanolic trimethylammonium EDTA. Retention in the matrix of water-soluble materials (e.g. proteoglycan) is much better than in standard aqueous EDTA demineralization procedures.

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