GK-11: a Novel Cationic Peptide with Antibiofilm Activity against Staphylococcus aureus and Pseudomonas aeruginosa

Simay Aldağ^{1

2}, Güler Tuba Buğdacı^{1

2}, Şeymanur Çobanoğlu^{1

2}, Erdem Erkengez^{1

2

3}, Mehmet Enes Arslan¹, Abdurrahim Kadı¹, Serkan Örtücü^{1

2}, Mesut Taşkın³, Ayşenur Yazıcı^{4

5}

Affiliations

¹ Faculty of Science, Molecular Biology and Genetics Department, Erzurum Technical University, Erzurum, Turkey.
² Molecular Microbiology Laboratory, Erzurum Technical University, High Technology Research and Application Centre (YUTAM), Erzurum, Turkey.
³ Faculty of Science, Molecular Biology and Genetics Department, Atatürk University, Erzurum, Turkey.
⁴ Faculty of Science, Molecular Biology and Genetics Department, Erzurum Technical University, Erzurum, Turkey. aysenur.ozdemir@erzurum.edu.tr.
⁵ Molecular Microbiology Laboratory, Erzurum Technical University, High Technology Research and Application Centre (YUTAM), Erzurum, Turkey. aysenur.ozdemir@erzurum.edu.tr.

Simay Aldağ et al. Probiotics Antimicrob Proteins. 2026.

. 2026 Mar 3.

doi: 10.1007/s12602-026-10963-6. Online ahead of print.

¹ Faculty of Science, Molecular Biology and Genetics Department, Erzurum Technical University, Erzurum, Turkey.
² Molecular Microbiology Laboratory, Erzurum Technical University, High Technology Research and Application Centre (YUTAM), Erzurum, Turkey.
³ Faculty of Science, Molecular Biology and Genetics Department, Atatürk University, Erzurum, Turkey.
⁴ Faculty of Science, Molecular Biology and Genetics Department, Erzurum Technical University, Erzurum, Turkey. aysenur.ozdemir@erzurum.edu.tr.
⁵ Molecular Microbiology Laboratory, Erzurum Technical University, High Technology Research and Application Centre (YUTAM), Erzurum, Turkey. aysenur.ozdemir@erzurum.edu.tr.

No abstract available

Keywords: Antibiofilm peptide; Caenorhabditis elegans; GK-11; Pseudomonas aeruginosa; Staphylococcus aureus.

Conflict of interest statement

Declarations. Competing Interests: The authors declare no competing interests.

1. Wang X, Liu M, Yu C, Li J, Zhou X (2023) Biofilm formation: mechanistic insights and therapeutic targets. Molecular biomedicine 4(1):49 - PubMed - PMC - DOI
1. Saharan BS, Beniwal N, Duhan JS (2024) From formulation to function: a detailed review of microbial biofilms and their polymer-based extracellular substances. The Microbe 5:100194 - DOI
1. Roilides E, Simitsopoulou M, Katragkou A, Walsh TJ (2015) How biofilms evade host defenses. Microb Biofilms :287–300
1. Vestby LK, Grønseth T, Simm R, Nesse LL (2020) Bacterial biofilm and its role in the pathogenesis of disease. Antibiotics 9(2):59 - PubMed - PMC - DOI
1. Percival SL, Suleman L, Vuotto C, Donelli G (2015) Healthcare-associated infections, medical devices and biofilms: risk, tolerance and control. J Med Microbiol 64(4):323–334 - PubMed - DOI