doi: 10.1084/jem.129.1.123.
Relative inability to induce tolerance in adult NZB and NZB-NZW F1 mice
- PMID: 4178111
- PMCID: PMC2138594
- DOI: 10.1084/jem.129.1.123
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Relative inability to induce tolerance in adult NZB and NZB-NZW F1 mice
J Exp Med.
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Abstract
Immunologic tolerance to ultracentrifuged bovine gamma globulin could not be induced in 6-wk old NZB or B/W mice, but developed readily in C3H, NZW, and C57Bl mice. NZB and B/W mice, as well as Balb/c mice, failed to become tolerant to ultracentrifuged human gamma globulin. The NZB and B/W mice also showed higher antibody titers to a standard antigenic challenge. This immunologic hyperreactivity and lack of experimental tolerance may be related to the lack of self-tolerance, autoimmunity, and lymphomas that develop in these mice at a later age.
