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. 1968 Sep;3(7):605-14.

Autoimmune haemolytic anaemias. I. Serological studies with pure anti-immunoglobulin reagents

C P Engelfriet, Borne AE vd, Giessen M vd, D Beckers, J J van Loghem

Autoimmune haemolytic anaemias. I. Serological studies with pure anti-immunoglobulin reagents

C P Engelfriet et al. Clin Exp Immunol. 1968 Sep.

Abstract

In this paper the preparation and examination of pure antisera against immunoglobulins is described. The results of serological studies obtained with pure anti-IgG, anti-IgM and anti-IgA sera as well as an anti-complement serum and the blood of four patients with acquired haemolytic anaemia are discussed. The presence of incomplete warm autoantibodies belonging to the G, M and A classes of immunoglobulins was demonstrated. Further, evidence was obtained that warm haemolysins are a separate antibody category independent of the presence of incomplete warm autoantibodies.

A new serological classification of the autoimmune haemolytic anaemias based on these findings is given.

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References

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