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. 2026 Mar 5.
doi: 10.1038/s41467-026-69405-0. Online ahead of print.

A gut microbiome-kidney-heart axis predictive of future cardiovascular diseases

Kanta Chechi #  1   2   3 , Rima Chakaroun #  4   5   6 , Antonis Myridakis #  7 , Sofia K Forslund-Startceva #  8   9   10   11 , Sebastien Fromentin #  12 , Trine Nielsen  13   14   15   16 , Judith Aron-Wisneswky  17   18 , Eugeni Belda  17   19 , Edi Prifti  17   19 , Pierre Bel Lassen  17   18 , Gwen Falony  20   21   22   23 , Sara Vieira-Silva  20   21   22   24   25 , Julien Chilloux  7 , Kazuhiro Sonomura  26 , Lesley Hoyles  7   27 , Laura Martinez-Gili  7 , Francesco Pallotti  7   28 , Petros Andrikopoulos  7 , Francesc Puig-Castellví  29 , Romina Pacheco Tapia  29 , Inés Castro-Dionicio  29 , Hugo Roume  12 , Nicolas Pons  12 , Emmanuelle Le Chatelier  12 , Benoit Quinquis  12 , Nathalie Galleron  12 , Magali Berland  12 , Michael T Olanipekun  7 , Manyi Jia  7 , Angelos Manolias  7 , Bridget Holmes  30   31 , Solia Adriouch  17 , Matthias Blüher  4   5 , Luis Pedro Coelho  32 , Kévin Da Silva  12 , Pilar Galan  33 , Boyang Ji  34   35 , Ana Luisa Neves  7   36 , Christine Rouault  17 , Joe-Elie Salem  37 , Valentina Tremaroli  6 , Tue H Hansen  13   14   15 , Nadja B Søndertoft  13 , Christian Lewinter  13 , Helle K Pedersen  13 ; MetaCardis Consortium; Peter D Mark  38 , Jens P Goetze  39 , Lars Køber  39   40 , Henrik Vestergaard  13   16 , Torben Hansen  13   41 , Jean-Daniel Zucker  17   19 , Taka-Aki Sato  26 , Serge Hercberg  33 , Fredrik Bäckhed  6   42 , Ivica Letunic  43   44 , Jean-Michel Oppert  18 , Jens Nielsen  34   35 , Jeroen Raes  20   21 , Ioanna Tzoulaki  45   46   47 , Abbas Dehghan  45   47 , Verena Zuber  45   47   48 , Emmanuelle Bouzigon  49 , Mark Lathrop  50 , Parminder Raina  51   52 , Philippe Froguel  29   53 , Fumihiko Matsuda  54 , Florence Demenais  49 , Dominique Gauguier  50   54   55 , Michael Stumvoll  4   5 , Peer Bork  9   32   44 , Oluf Pedersen  56   57   58 , S Dusko Ehrlich  59   60 , Karine Clément  61   62 , Marc-Emmanuel Dumas  63   64   65   66
Collaborators, Affiliations
Free article

A gut microbiome-kidney-heart axis predictive of future cardiovascular diseases

Kanta Chechi et al. Nat Commun. .
Free article

Abstract

Cardiovascular diseases (CVD) remain a major global health challenge. Early markers of disease initiation and progression are urgently needed. We, and others, have previously shown changes in the gut microbiome in association with metabolic and CVD. Here, we demonstrate that gut microbiome-related changes can be detected in association with subclinical variations in heart and kidney function. Markers related to gut microbial metabolism of aromatic amino acids, phenylalanine and tyrosine, associate with circulating pro-atrial natriuretic peptide and estimated glomerular filtration rate in a metabolically healthy European population. Observational and genetic evidence further identify microbiome-related metabolites as mediators of this gut microbiome-kidney axis, with their baseline levels associating with incident CVD in an external Canadian population. Altogether, our work suggests that the gut microbiome interacts with the cardiorenal axis and participates in an interorgan crosstalk affecting host physiology and risk of CVD.

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Conflict of interest statement

Competing interests: K.Cle. has held a collaborative research contract with Danone Research in the context of MetaCardis project. O.P. is a co-founder of GutCRINE. F.B. is shareholder of Implexion pharma AB and Roxbiosens, receives research grants from Biogaia AB and Novo Nordisk A/S and is on the scientific advisory board of Bactolife A/S. V.T. is shareholder of Roxbiosens. K.S. and T.A.S. are employees of Shimadzu, Kyoto, Japan. M.Blu. received honoraria as a consultant and speaker from Amgen, AstraZeneca, Bayer, Boehringer Ingelheim, Daiichi-Sankyo, Lilly, Novo Nordisk, Novartis, and Sanofi. The remaining authors declare no competing interests.

References

    1. The Global Cardiovascular Risk Consortium. Global effect of modifiable risk factors on cardiovascular disease and mortality. N. Eng. J. Med. 389, 1273–1285 (2023).
    1. Vollset, S. E. et al. Burden of disease scenarios for 204 countries and territories, 2022–2050: a forecasting analysis for the Global Burden of Disease Study 2021. Lancet. 403, 2204–2256 (2024).
    1. Fan, Y. & Pedersen, O. Gut microbiota in human metabolic health and disease. Nat. Rev. Microbiol. 19, 55–71 (2021).
    1. Keshet, A. & Segal, E. Identification of gut microbiome features associated with host metabolic health in a large population-based cohort. Nat. Commun. 15, 9358 (2024).
    1. Gacesa, R. et al. Environmental factors shaping the gut microbiome in a Dutch population. Nature 604, 732–739 (2022).

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