Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 1977 Dec:21:65-9.
doi: 10.1289/ehp.772165.

Mutagenicity of the halogenated olefin, 2-bromo-2-chloro-1,1-difluoroethylene, a presumed metabolite of the inhalation anesthetic halothane

A J Garro, R A Phillips

Mutagenicity of the halogenated olefin, 2-bromo-2-chloro-1,1-difluoroethylene, a presumed metabolite of the inhalation anesthetic halothane

A J Garro et al. Environ Health Perspect. 1977 Dec.

Abstract

The presumed halothane metabolite, 2-bromo-1,1-difluoroethylene, produces both base substitution and frameshift mutations in Salmonella typhimurium. Direct mutagenesis of isolated DNA also was observed by using a Bacillus subtils transformation assay to score the production of mutagenic lesions in transforming DNA.

PubMed Disclaimer

Similar articles

See all similar articles

Cited by

References

    1. Proc Natl Acad Sci U S A. 1962 Oct 15;48:1796-803 - PubMed
    1. Environ Health Perspect. 1977 Dec;21:1-5 - PubMed
    1. J Bacteriol. 1970 Mar;101(3):844-50 - PubMed
    1. J Bacteriol. 1966 Jul;92(1):229-40 - PubMed
    1. Lancet. 1974 Jun 29;1(7870):1316-8 - PubMed

MeSH terms

LinkOut - more resources