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. 1968 Mar 15;159(3820):1243-4.
doi: 10.1126/science.159.3820.1243.

Transformation of human lymphocytes: inhibition by homologous alpha globulin

S R Cooperband, H Bondevik, K Schmid, J A Mannick

Transformation of human lymphocytes: inhibition by homologous alpha globulin

S R Cooperband et al. Science. .

Abstract

An alpha globulin fraction prepared from normal human plasma by column chromatography prevents homologous lymphocyte transformation and the stimulation of DNA, and also protein synthesis induced by phytohemagglutinin and specific antigens. These observations support the concept of a normal circulating immunosuppressant factor which prevents lymphoid cell proliferation.

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