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Editorial
. 2026 Feb 28;18(2):52.
doi: 10.21037/jtd-2025-1940. Epub 2026 Feb 4.

High-flow nasal oxygen versus noninvasive ventilation in acute respiratory failure: reflections on the RENOVATE trial

Alexander Bracey  1 , David H Gordon  2 , Brian J Wright  3
Affiliations
Editorial

High-flow nasal oxygen versus noninvasive ventilation in acute respiratory failure: reflections on the RENOVATE trial

Alexander Bracey et al. J Thorac Dis. .
No abstract available

Keywords: RENOVTE; critical care; high-flow nasal oxygen (HFNO); noninvasive ventilation (NIV); resuscitation.

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Conflict of interest statement

Conflicts of Interest: All authors have completed the ICMJE uniform disclosure form (available at https://jtd.amegroups.com/article/view/10.21037/jtd-2025-1940/coif). A.B. is a medical consultant for Verathon, Inc. and BD. He has investment in Powerful Medical., Inc. B.J.W. has received honorarium to participate and lecture on critical care topics. He has also invested in a company that is developing an app that uses AI to interpret ECGs. Neither is relevant to this topic. The other author has no conflicts of interest to declare.

Comment on

  • High-Flow Nasal Oxygen vs Noninvasive Ventilation in Patients With Acute Respiratory Failure: The RENOVATE Randomized Clinical Trial.
    RENOVATE Investigators and the BRICNet Authors; Maia IS, Kawano-Dourado L, Tramujas L, de Oliveira NE, Souza RN, Signorini DF, Pincelli MP, Zandonai CL, Blasius RT, Freires F, Ferreira VM, Romano MLP, Miura MC, de Censo CM, Caser EB, Silva B, Santos Bonomo DC, Arraes JA, de Alencar Filho MS, Álvares Horta JG, Oliveira DC, Boschi E, Costa RL, Westphal GA, Ramos J, Lacerda FH, Filho CRH, Pinheiro BV, de Andrade Neumamm LB, Guimarães Júnior MRR, de Souza DT, Ferreira JC, Ohe LN, Schettini DA, Thompson MM, de Oliveira MCF, Veiga VC, Negrelli KL, Santos RHN, Damiani L, Gurgel RM, Gomes SPC, Lima LM, Miranda TA, Laranjeira LN, de Barros E Silva PGM, Machado FR, Fitzgerald M, Bosse A, Marion J, Carvalho CRR, Brochard L, Lewis RJ, Biasi Cavalcanti A. RENOVATE Investigators and the BRICNet Authors, et al. JAMA. 2025 Mar 11;333(10):875-890. doi: 10.1001/jama.2024.26244. JAMA. 2025. PMID: 39657981 Free PMC article. Clinical Trial.

References

    1. Maia IS, Kawano-Dourado L, Tramujas L, et al. High-Flow Nasal Oxygen vs Noninvasive Ventilation in Patients With Acute Respiratory Failure: The RENOVATE Randomized Clinical Trial. JAMA 2025;333:875-90. 10.1001/jama.2024.26244 - DOI - PMC - PubMed
    1. Frat JP, Thille AW, Mercat A, et al. High-flow oxygen through nasal cannula in acute hypoxemic respiratory failure. N Engl J Med 2015;372:2185-96. 10.1056/NEJMoa1503326 - DOI - PubMed
    1. Tan D, Wang B, Cao P, et al. High flow nasal cannula oxygen therapy versus non-invasive ventilation for acute exacerbations of chronic obstructive pulmonary disease with acute-moderate hypercapnic respiratory failure: a randomized controlled non-inferiority trial. Crit Care 2024;28:250. 10.1186/s13054-024-05040-9 - DOI - PMC - PubMed
    1. Yamane DP, Jones CW, Wilkerson RG, et al. High-velocity nasal insufflation versus noninvasive positive pressure ventilation for moderate acute exacerbation of chronic obstructive pulmonary disease in the emergency department: A randomized clinical trial. Acad Emerg Med 2025;32:403-13. 10.1111/acem.15038 - DOI - PMC - PubMed
    1. Osadnik CR, Tee VS, Carson-Chahhoud KV, et al. Non-invasive ventilation for the management of acute hypercapnic respiratory failure due to exacerbation of chronic obstructive pulmonary disease. Cochrane Database Syst Rev 2017;7:CD004104. 10.1002/14651858.CD004104.pub4 - DOI - PMC - PubMed

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