Patch Test Results With the European Baseline Series, 2021/2022-Joint European Results of the ESSCA^A and the EBS^B Working Groups of the ESCD, and the GEIDAC^C

Wolfgang Uter¹, S Mark Wilkinson², Olivier Aerts³, Andrea Bauer⁴, Leopoldo Borrego⁵, Richard Brans⁶, Timo Buhl⁷, Heinrich Dickel⁸, Aleksandra Dugonik⁹, Francesca Larese Filon¹⁰, Ana Giménez Arnau¹¹, Cataldo Patruno¹², Györgyi Pónyai¹³, Stamatis Gregoriou¹⁴, Steffen Schubert¹⁵, Dagmar Simon¹⁶, Luca Stingeni¹⁷, Skaidra Valiukevičienė¹⁸, Elke Weisshaar¹⁹, Thomas Werfel²⁰, Margarida Gonçalo²¹, Marie-L A Schuttelaar²²; ESSCAA and EBSB ESCD Working Groups, and the GEIDACC

Collaborators, Affiliations

Collaborators

ESSCAA and EBSB ESCD Working Groups, and the GEIDACC:
Birger Kränke, Alexander Navarini, Philip Spring, Ulrike Beiteke, Cecilia Dietrich, Sibylle Schliemann, Detlef Becker, Swen Malte John, Nicola Wagner, Dimitra Koumaki, Maddalena Napolitano, Anna Belloni Fortina, Francesca Larese Filon, Rosella Gallo, Thomas Rustemeyer, Radoslaw Spiewak, Maja Kalac Pandurovic, Tanja Kmecl, Mojca Simončič Godnič, Nada Kecelj, Philippa Cousen, Ella Dendooven, Juan Francisco Silvestre Salvador, José Manuel Carrascosa Carrillo, Mónica Munera Campos, Esther Serra Baldrich, Gemma Melé-Ninot, Cristina Barrabés Torrella, David Pesqué, María Antonia Pastor Nieto, Francisco Navarro Triviño, Inmaculada Ruiz Gonzales, Enrique Gómez de la Fuente, Susana Córdoba Guijarro, Francisco Javier Ortiz de Frutos, Fátima Tous Romero, Tatiana Sanz Sánchez, Pablo Chicharro Manso, Marta Andreu Barasoain, Marta Elosua González, Araceli Sánchez Gilo, Paloma Sánchez-Pedreño Guillén, Pedro Mercader-García, Carmen Paredes Suárez, María Elena Gatica Ortega, José Juan Pereyra Rodríguez, Javier Miquel Miquel, Mercedes Rodríguez Serna, Violeta Zaragoza Ninet, Ricardo González Pérez

Affiliations

¹ Department of Medical Informatics, Biometry and Epidemiology, Friedrich-Alexander-Universität Erlangen-Nürnberg, Erlangen, Germany.
² Dermatology Department, Leeds Teaching Hospitals NHS Trust, Leeds, UK.
³ Department of Dermatology, University Hospital Antwerp (UZA) and Research Group Immunology, Infla-Med Centre of Excellence, University of Antwerp, Antwerp, Belgium.
⁴ Department of Dermatology, University Hospital Carl Gustav Carus, Technical University, Dresden, Germany.
⁵ Complejo Hospitalario Universitario Insular Materno Infantil, Universidad de Las Palmas de Gran Canaria, Las Palmas de Gran Canaria, Spain.
⁶ Institute for Interdisciplinary Dermatologic Prevention and Rehabilitation (iDerm) at the Osnabrück University, Osnabrück, Germany.
⁷ Department of Dermatology, Venereology and Allergology, University Medical Center Göttingen, Göttingen, Germany.
⁸ Department of Dermatology, Venereology and Allergology, St. Josef Hospital, University Medical Center, Ruhr University Bochum, Bochum, Germany.
⁹ Department of Dermatology, University Medical Centre Maribor, Maribor, Slovenia.
¹⁰ Department of Medical, Surgical and Health Sciences, Occupational Medicine, University of Trieste, Trieste, Italy.
¹¹ Department of Dermatology, Hospital del Mar, Research Institute, Universitat Pompeu Fabra de Barcelona, Barcelona, Spain.
¹² Department of Medicine and Health Sciences "Vincenzo Tiberio", University of Molise, Campobasso, Italy.
¹³ Department of Dermatology, Venerology and Dermato-Oncology, Semmelweis University, Budapest, Hungary.
¹⁴ Department of Dermatology, Faculty of Medicine, National and Kapodistrian University of Athens, Athens, Greece.
¹⁵ Information Network of Departments of Dermatology (IVDK), Institute at the Georg-August University Göttingen, University Medical Centre Göttingen, Göttingen, Germany.
¹⁶ Department of Dermatology, Inselspital, Bern University Hospital, University of Bern, Bern, Switzerland.
¹⁷ Dermatology Section, Department of Medicine and Surgery, University of Perugia, Perugia, Italy.
¹⁸ Department of Skin and Venereal Diseases, The Hospital of Lithuanian University of Health Sciences Kauno Klinikos, Kaunas, Lithuania.
¹⁹ Occupational Dermatology, Department of Dermatology, University Hospital Heidelberg, Heidelberg, Germany.
²⁰ Department of Dermatology and Allergy, Hannover Medical School, Hannover, Germany.
²¹ Department of Dermatology, University Hospital and Faculty of Medicine, University of Coimbra, Coimbra, Portugal.
²² Department of Dermatology, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands.

PMID: 41819607
DOI: 10.1111/cod.70134

Patch Test Results With the European Baseline Series, 2021/2022-Joint European Results of the ESSCA^A and the EBS^B Working Groups of the ESCD, and the GEIDAC^C

Wolfgang Uter et al. Contact Dermatitis. 2026.

. 2026 Mar 12.

doi: 10.1111/cod.70134. Online ahead of print.

Authors

Collaborators

ESSCAA and EBSB ESCD Working Groups, and the GEIDACC:
Birger Kränke, Alexander Navarini, Philip Spring, Ulrike Beiteke, Cecilia Dietrich, Sibylle Schliemann, Detlef Becker, Swen Malte John, Nicola Wagner, Dimitra Koumaki, Maddalena Napolitano, Anna Belloni Fortina, Francesca Larese Filon, Rosella Gallo, Thomas Rustemeyer, Radoslaw Spiewak, Maja Kalac Pandurovic, Tanja Kmecl, Mojca Simončič Godnič, Nada Kecelj, Philippa Cousen, Ella Dendooven, Juan Francisco Silvestre Salvador, José Manuel Carrascosa Carrillo, Mónica Munera Campos, Esther Serra Baldrich, Gemma Melé-Ninot, Cristina Barrabés Torrella, David Pesqué, María Antonia Pastor Nieto, Francisco Navarro Triviño, Inmaculada Ruiz Gonzales, Enrique Gómez de la Fuente, Susana Córdoba Guijarro, Francisco Javier Ortiz de Frutos, Fátima Tous Romero, Tatiana Sanz Sánchez, Pablo Chicharro Manso, Marta Andreu Barasoain, Marta Elosua González, Araceli Sánchez Gilo, Paloma Sánchez-Pedreño Guillén, Pedro Mercader-García, Carmen Paredes Suárez, María Elena Gatica Ortega, José Juan Pereyra Rodríguez, Javier Miquel Miquel, Mercedes Rodríguez Serna, Violeta Zaragoza Ninet, Ricardo González Pérez

Affiliations

¹ Department of Medical Informatics, Biometry and Epidemiology, Friedrich-Alexander-Universität Erlangen-Nürnberg, Erlangen, Germany.
² Dermatology Department, Leeds Teaching Hospitals NHS Trust, Leeds, UK.
³ Department of Dermatology, University Hospital Antwerp (UZA) and Research Group Immunology, Infla-Med Centre of Excellence, University of Antwerp, Antwerp, Belgium.
⁴ Department of Dermatology, University Hospital Carl Gustav Carus, Technical University, Dresden, Germany.
⁵ Complejo Hospitalario Universitario Insular Materno Infantil, Universidad de Las Palmas de Gran Canaria, Las Palmas de Gran Canaria, Spain.
⁶ Institute for Interdisciplinary Dermatologic Prevention and Rehabilitation (iDerm) at the Osnabrück University, Osnabrück, Germany.
⁷ Department of Dermatology, Venereology and Allergology, University Medical Center Göttingen, Göttingen, Germany.
⁸ Department of Dermatology, Venereology and Allergology, St. Josef Hospital, University Medical Center, Ruhr University Bochum, Bochum, Germany.
⁹ Department of Dermatology, University Medical Centre Maribor, Maribor, Slovenia.
¹⁰ Department of Medical, Surgical and Health Sciences, Occupational Medicine, University of Trieste, Trieste, Italy.
¹¹ Department of Dermatology, Hospital del Mar, Research Institute, Universitat Pompeu Fabra de Barcelona, Barcelona, Spain.
¹² Department of Medicine and Health Sciences "Vincenzo Tiberio", University of Molise, Campobasso, Italy.
¹³ Department of Dermatology, Venerology and Dermato-Oncology, Semmelweis University, Budapest, Hungary.
¹⁴ Department of Dermatology, Faculty of Medicine, National and Kapodistrian University of Athens, Athens, Greece.
¹⁵ Information Network of Departments of Dermatology (IVDK), Institute at the Georg-August University Göttingen, University Medical Centre Göttingen, Göttingen, Germany.
¹⁶ Department of Dermatology, Inselspital, Bern University Hospital, University of Bern, Bern, Switzerland.
¹⁷ Dermatology Section, Department of Medicine and Surgery, University of Perugia, Perugia, Italy.
¹⁸ Department of Skin and Venereal Diseases, The Hospital of Lithuanian University of Health Sciences Kauno Klinikos, Kaunas, Lithuania.
¹⁹ Occupational Dermatology, Department of Dermatology, University Hospital Heidelberg, Heidelberg, Germany.
²⁰ Department of Dermatology and Allergy, Hannover Medical School, Hannover, Germany.
²¹ Department of Dermatology, University Hospital and Faculty of Medicine, University of Coimbra, Coimbra, Portugal.
²² Department of Dermatology, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands.

PMID: 41819607
DOI: 10.1111/cod.70134

Abstract

Background: Patch test results obtained with the European Baseline Series (EBS) in its current version serve both contact allergy surveillance and (re-)assessing the diagnostic value of EBS allergens.

Objectives: To present results of current EBS patch testing, obtained in 59 departments in 14 European countries during 2021 and 2022.

Methods: Anonymised or pseudonymised individual data, and partly aggregated results, on demographic/clinical characteristics and patch test results with the EBS were prospectively collected, centrally pooled, and retrospectively analysed.

Results: In 2021 and 2022, 18 832 patients were patch tested with the EBS. Sensitization to nickel remained most common (18.85 (18.29-19.43)% positivity (95% confidence interval)). Fragrance mix I and Myroxylon pereirae resin yielded very similar results with 6.39 (6.04-6.76)% and 6.5 (6.15-6.87)% positivity, respectively. Concerning preservatives, methylchloroisothiazolinone/methylisothiazolinone (MCI/MI) 0.02% aq. yielded 5.52 (5.11-5.96)% and MI 0.2% aq. yielded 5.28 (4.94-5.64)% positives. Testing formaldehyde 2% aq. identified almost one percentage point more positive reactions than 1% aq. (2.05 (1.81-2.32)% vs. 1.22 (0.99-1.48)). Positive reactions to the recently added allergens were most frequently seen to propolis (5.47 (5.12-5.84)%) and 2-hydroxyethyl methacrylate (3.63 (3.32-3.96)%).

Conclusions: Compared to the previous reporting period, surveillance results with the EBS were mostly stable. The results regarding Quaternium 15 (0.4 (0.29-0.53)% positives) justified its exclusion from the 2023 EBS version.

Keywords: RRID:SCR_001905; baseline series; clinical epidemiology; contact allergy; patch testing; surveillance.

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References

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1. S. M. Wilkinson, S. Badulici, A. Giménez‐Arnau, et al., “The European Baseline Series: Criteria for Allergen Inclusion (With Reference to Formaldehyde Releasers),” Contact Dermatitis 85 (2021): 125–128, https://doi.org/10.1111/cod.13836.
1. S. M. John, A. Bonertz, J. Zimmer, et al., “Severely Compromised Supply of Patch Test Allergens in Europe Hampers Adequate Diagnosis of Occupational and Non‐Occupational Contact Allergy. A European Society of Contact Dermatitis (ESCD), European Academy of Allergy and Clinical Immunology (EAACI), European Academy of Dermatology and Venereology (EADV) Task Forces ‘Contact Dermatitis’ and ‘Occupational Skin Disease’ Position Paper,” Contact Dermatitis 91, no. 2 (2024): 91–103, https://doi.org/10.1111/cod.14580.
1. C. P. Hernández‐Fernández, P. Mercader‐García, J. F. Silvestre Salvador, et al., “Candidate Allergens for Inclusion in the Spanish Standard Series Based on Data From the Spanish Contact Dermatitis Registry,” Actas Dermo‐Sifiliográficas (English Edition) 112, no. 9 (2021): 798–805, https://doi.org/10.1016/j.adengl.2021.07.013.
1. M. Wilkinson, M. Gonçalo, O. Aerts, et al., “The European Baseline Series and Recommended Additions: 2019,” Contact Dermatitis 80, no. 1 (2019): 1–4, https://doi.org/10.1111/cod.13155.

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Patch Test Results With the European Baseline Series, 2021/2022-Joint European Results of the ESSCA^A and the EBS^B Working Groups of the ESCD, and the GEIDAC^C

Collaborators

Affiliations

Patch Test Results With the European Baseline Series, 2021/2022-Joint European Results of the ESSCA^A and the EBS^B Working Groups of the ESCD, and the GEIDAC^C

Authors

Collaborators

Affiliations

Abstract

References

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