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. 1969 Jun 27;164(3887):1524-5.
doi: 10.1126/science.164.3887.1524.

Limited periods of gene expression in immunoglobulin-synthesizing cells

Limited periods of gene expression in immunoglobulin-synthesizing cells

D N Buell et al. Science. .

Abstract

In synchronized human lymphoid cell lines, production of immunoglobulins G and M is greatest during the late Gl and S phases of the cell cycle. Little immunoglobulin appears immediately before, during, and immediately after mitosis. The results indicate that transcription of immunoglobulin genes takes place during a limited part of the mitotic cycle.

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