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Review
. 2026 Mar 13;7(3):101042.
doi: 10.1016/j.medj.2026.101042.

Methodological pitfalls in mild Crohn's disease clinical trials

Maria Manuela Estevinho  1 , Iago Rodríguez-Lago  2 , Sophie Restellini  3 , Julien Kirchgesner  4 , Nurulamin M Noor  5
Affiliations
Review

Methodological pitfalls in mild Crohn's disease clinical trials

Maria Manuela Estevinho et al. Med. .

Abstract

There has been much interest in the potential role of diet as a therapeutic option in Crohn's disease (CD). Several recent dietary clinical trials have been reported in "mild" Crohn's disease. Herein, we highlight several methodological pitfalls from these short-term dietary trials in mild CD that should be considered to enable appropriate interpretation by patients and clinicians.

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Conflict of interest statement

Declaration of interests M.M.E. reports speaker fees from Celltrion, Dr. Falk, J&J, and Lilly. I.R.-L. reports financial support for traveling and educational activities from or has served as an advisory board member for AbbVie, Adacyte, Alfasigma, Biogen, Faes Farma, Ferring, Galapagos, J&J, Lilly, Merck, Mirum Pharmaceuticals, Pfizer, Roche, Takeda, and Tillotts. I.R.-L has received research support from AbbVie and Alfasigma. S.R. reports speaker fees and/or advisory board member fees from AbbVie, BMS, Dr. Falk, Ferring, iQone, J&J, Lilly, Sandoz, Takeda, UCB, and Vifor. J.K. reports consulting and/or speaker fees from AbbVie, Amgen, Alfasigma, Celltrion, Ferring, Galapagos, J&J, Lilly, MSD, Pfizer, Resilience, Takeda, Theradiag, and Tillotts. N.M.N. reports educational/travel grants and/or speaker fees and/or advisory board fees from AbbVie, BMS, Celltrion, Dr. Falk, Ferring, Galapagos, J&J, Lilly, Pfizer, Pharmacosmos, Takeda, and Tillotts.

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