Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Comparative Study
. 1978 Mar;75(3):1153-6.
doi: 10.1073/pnas.75.3.1153.

Multiple receptors for brain dopamine

M Titeler, P Weinreich, D Sinclair, P Seeman
Comparative Study

Multiple receptors for brain dopamine

M Titeler et al. Proc Natl Acad Sci U S A. 1978 Mar.

Abstract

This study was done to obtain direct in vitro evidence for the possible existence of more than one type of dopaminergic binding site in homogenates of the caudate nucleus from calf brain. Five radioligands for dopaminergic sites were tested. The inhibitions of two agonist radioligands ([3H]dopamine, [3H]apomorphine) by haloperidol, chlorpromazine, or piflutixol were biphasic. The inhibitions of [3H]haloperidol, [3H]spiroperidol, and [3H]dihydroergocryptine binding by dopamine and (-)-norepinephrine were also biphasic. Thus, both 3H-labeled agonists and 3H-labeled antagonists were possibly binding to two high-affinity sites.

PubMed Disclaimer

References

    1. Biochem Pharmacol. 1977 Oct 1;26(19):1741-8 - PubMed
    1. Naunyn Schmiedebergs Arch Pharmacol. 1976 Dec;296(1):5-14 - PubMed
    1. Proc Natl Acad Sci U S A. 1976 Dec;73(12):4354-8 - PubMed
    1. Naunyn Schmiedebergs Arch Pharmacol. 1977 Mar;297(2):111-7 - PubMed
    1. Proc Natl Acad Sci U S A. 1977 Sep;74(9):3750-3 - PubMed

Publication types

LinkOut - more resources