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. 1978 Feb;72(1):45-54.
doi: 10.1080/00034983.1978.11719278.

Mode of action of the 2-nitroimidazole derivative benznidazole

A Polak, R Richle

Mode of action of the 2-nitroimidazole derivative benznidazole

A Polak et al. Ann Trop Med Parasitol. 1978 Feb.

Abstract

Using cultures of Trypanosoma cruzi cells in a liquid medium, the mode of action of the 2-nitroimidazole derivative benznidazole was examined. Benznidazole inhibits protein synthesis and RNA synthesis in T. cruzy. The DNA synthesis is only slightly decreased and no effect on the aerobic respiration of T. cruzi was observed.

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