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. 1978;48(1):1-8.

Inhibition of DMBA-induced carcinogenesis by phenformin in the mammary gland of rats

V M Dilman, L M Berstein, M A Zabezhinski, V A Alexandrov, J F Bobrov, G B Pliss
  • PMID: 418748

Inhibition of DMBA-induced carcinogenesis by phenformin in the mammary gland of rats

V M Dilman et al. Arch Geschwulstforsch. 1978.

Abstract

It is shown that daily oral administration of 5--10 mg of an antidiabetic biguanide-phenformin (phenethyl-biguanide) for 2.5--5 months suppressed DMBA-induced mammary tumour development in rats considerably. Phenformin-treated rats revealed-a tendency towards a decrease in blood insulin level (radioimmunoassay). The obtained data are regarded as additional evidence for the proposed existence of the same metabolic background of diseases of compensation, i.e. adult-onset diabetes, artherosclerosis and cancer, and suggest studies on possible antitumour effect of phenformin in man.

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