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. 1978 May 1;171(2):337-47.
doi: 10.1042/bj1710337.

Sequence of the full-length immunoglobulin kappa-chain of mouse myeloma MPC 11

G P Smith

Sequence of the full-length immunoglobulin kappa-chain of mouse myeloma MPC 11

G P Smith. Biochem J. .

Abstract

MPC 11 mouse myeloma cells synthesize two immunoglobulin kappa light chains, coded by two separate genes. One of these Kappa-chains has no variable region and is degraded intracellularly. The other is a full-length kappa-chain contaning both variable and constant regions: this chain is secreted, both by itself and combined with heavy chains in molecules of immunoglobulin G. This paper reports the amino acid sequence of the myeloma MPC 11 full-length kappa-chain. The chain is unusual in having 12 extra residues at its N-terminus when its sequence is aligned with those of other mouse kappa-chains; no other anomalies were found in its sequence.

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References

    1. Proc Natl Acad Sci U S A. 1977 Feb;74(2):716-20 - PubMed
    1. Eur J Biochem. 1967 Mar;1(1):80-91 - PubMed
    1. Biochemistry. 1973 Feb;12(4):749-59 - PubMed
    1. Hoppe Seylers Z Physiol Chem. 1971 Dec;352(12):1730-2 - PubMed
    1. Nat New Biol. 1972 Sep 27;239(91):117-20 - PubMed

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