[Effect of methotrexate on glycolysis of leukemia L 1210 cells cultivated in vitro]
[Article in
French]
- PMID: 418900
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[Effect of methotrexate on glycolysis of leukemia L 1210 cells cultivated in vitro]
[Article in
French]
C R Acad Hebd Seances Acad Sci D.
.
Abstract
Methotrexate, at non lethal doses, alters the glycolysis of leukaemic L 1210 cells. Glucose uptake and lactate excretion are increased but lactate/glucose ratio remains constant. The activity of glycolytic enzymes in the cytoplasm is increased and the level of intracellular ATP is greatly enhanced.
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