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. 1978 Jan 30;286(4):375-7.

[Effect of methotrexate on glycolysis of leukemia L 1210 cells cultivated in vitro]

[Article in French]
Y Carpentier, B Desoize, C Rollet, J C Jardillier
  • PMID: 418900

[Effect of methotrexate on glycolysis of leukemia L 1210 cells cultivated in vitro]

[Article in French]
Y Carpentier et al. C R Acad Hebd Seances Acad Sci D. .

Abstract

Methotrexate, at non lethal doses, alters the glycolysis of leukaemic L 1210 cells. Glucose uptake and lactate excretion are increased but lactate/glucose ratio remains constant. The activity of glycolytic enzymes in the cytoplasm is increased and the level of intracellular ATP is greatly enhanced.

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