[Preparation and experimental antitumor activity of a new semi-synthetic antibiotic: 14-diethoxyacetoxy daunorubicin (R.P. 33 921)]
- PMID: 418906
[Preparation and experimental antitumor activity of a new semi-synthetic antibiotic: 14-diethoxyacetoxy daunorubicin (R.P. 33 921)]
Abstract
14-diethoxyacetoxy daunorubicin (R.P. 33 921) was chosen among a series of new daunorubicin analogues. Its preparation from daunorubicin and its biological activities are described. It displays an antitumoral activity in mice with a better chemotherapeutic index than daunorubicin and doxorubicin.
Similar articles
-
Biological activities of rubidazone.Cancer Chemother Pharmacol. 1979;2(1):31-5. doi: 10.1007/BF00253102. Cancer Chemother Pharmacol. 1979. PMID: 498417
-
Adriamycin analogues. Novel anomeric ribofuranoside analogues of daunorubicin.J Med Chem. 1982 Jan;25(1):28-31. doi: 10.1021/jm00343a006. J Med Chem. 1982. PMID: 7086818
-
Syntheses and antitumor activities of 7-O-(2,6-dideoxy-2-fluoro-alpha-L-talopyranosyl)-daunomycinone and -adriamycinone.J Antibiot (Tokyo). 1986 May;39(5):731-3. doi: 10.7164/antibiotics.39.731. J Antibiot (Tokyo). 1986. PMID: 3733524 No abstract available.
-
Antitumor antibiotic carminomycin.Z Allg Mikrobiol. 1980;20(3):219-25. Z Allg Mikrobiol. 1980. PMID: 6158803 Review. No abstract available.
-
Daunorubicin and doxorubicin, anthracycline antibiotics, a physicochemical and biological review.Biochimie. 1984 May;66(5):333-52. doi: 10.1016/0300-9084(84)90018-x. Biochimie. 1984. PMID: 6380596 Review.
Cited by
-
Comparative toxicity of detorubicin and doxorubicin, free and DNA-bound, for hemopoietic stem cells.Cancer Chemother Pharmacol. 1980;5(2):79-82. doi: 10.1007/BF00435408. Cancer Chemother Pharmacol. 1980. PMID: 7471318
-
Cancer chemotherapy: new developments and changing concepts.Drugs. 1980 Nov;20(5):375-97. doi: 10.2165/00003495-198020050-00003. Drugs. 1980. PMID: 7002528 Review. No abstract available.
-
Preliminary results of a phase II trial of aclacinomycin in acute leukaemia and lymphosarcoma. An oncostatic anthracyclin that is rarely cardiotoxic and induces no alopecia.Cancer Chemother Pharmacol. 1978;1(4):259-62. doi: 10.1007/BF00257160. Cancer Chemother Pharmacol. 1978. PMID: 373923 Clinical Trial.