doi: 10.1126/science.168.3933.852.
Immune responses of inbred mice to repeated low doses of antigen: relationship to histocompatibility (H-2) type
- PMID: 4192080
- DOI: 10.1126/science.168.3933.852
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Immune responses of inbred mice to repeated low doses of antigen: relationship to histocompatibility (H-2) type
Science.
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Abstract
Immunization of inbred strains of mice with repeated minute doses (0.1 to 1.0 microgram) of hapten-protein conjugates demonstrated wide differences in the magnitude of their antibody responses, which were related to the histocompatibility (H-2) type of the strains. Immunization with a single high dose (100 micrograms) of antigen failed to demonstrate these differences.
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