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. 1970 Mar;65(3):551-6.
doi: 10.1073/pnas.65.3.551.

Cellular sites of immunologic unresponsiveness

J M Chiller, G S Habicht, W O Weigle

Cellular sites of immunologic unresponsiveness

J M Chiller et al. Proc Natl Acad Sci U S A. 1970 Mar.

Abstract

The reconstitution of the immune response of lethally irradiated mice to human gamma-globulin is dependent on the synergistic action of bone marrow with thymus cells. Immunologic unresponsiveness appears to involve a functional defect at each of these cellular levels, inasmuch as neither bone marrow nor thymus cells from unresponsive donors are capable of demonstrating synergism in combination with their normal counterpart.

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References

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