Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 1970 Jun;18(6):909-20.

Intestinal secretion of immunoglobulins and antibodies to Escherichia coli in the pig

P Porter, D E Noakes, W D Allen

Intestinal secretion of immunoglobulins and antibodies to Escherichia coli in the pig

P Porter et al. Immunology. 1970 Jun.

Abstract

Immunoglobulins and antibodies against Escherichia coli 0141 have been studied in porcine intestinal secretions obtained from Thiry Vella loops prepared in the mid jejunum of 4 animals.

The molecular size of the secreted immunoglobulins were investigated by gel filtration and sucrose density gradient ultra-centrifugation. Intestinal IgM was found to have 7S characteristics and intestinal IgA mainly 11S characteristics similar to secretory IgA isolated from porcine milk.

Immune inhibition studies with rabbit anti-IgA-globulin serum produced complete elimination of E. coli 0141 antibodies detected by direct haemagglutination. In one animal incomplete antibody assayed by antiglobulin haemagglutination was identified in fractions associated with IgM and IgG.

Immunofluorescent studies were made to correlate immunoglobulins in the small intestinal tissue with weaning.

PubMed Disclaimer

References

    1. Experientia. 1970 Jan 15;26(1):90-2 - PubMed
    1. Adv Immunol. 1968;9:1-96 - PubMed
    1. J Immunol. 1950 Jul;65(1):93-103 - PubMed
    1. J Clin Invest. 1967 Aug;46(8):1329-37 - PubMed
    1. Lancet. 1968 Apr 27;1(7548):884-6 - PubMed

LinkOut - more resources