doi: 10.1128/JVI.11.5.748-755.1973.
Rabies group-specific ribonucleoprotein antigen and a test system for grouping and typing of rhabdoviruses
- PMID: 4196634
- PMCID: PMC355172
- DOI: 10.1128/JVI.11.5.748-755.1973
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Rabies group-specific ribonucleoprotein antigen and a test system for grouping and typing of rhabdoviruses
J Virol.
1973 May.
Abstract
Cell-associated ribonucleoprotein (RNP) was isolated from BHK-21 cells infected with several strains of rabies and rabies-related viruses. The RNP-antigen from rabies and related viruses induced the formation of complement-fixing, precipitating, and immunofluorescent antibodies, and proved to be the group-specific antigen common to all rabies viruses. Antigens of the envelope which induce virus-neutralizing antibodies are apparently determinative for the serotype of a virus as evidenced by two-way neutralization tests. A combination of these methods seems to be a useful approach to the serological grouping and typing of rhabdoviruses.
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