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Review
. 1973 May;70(5):1456-60.
doi: 10.1073/pnas.70.5.1456.

Conformational analysis of thyrotropin releasing factor

A W Burgess, F A Momany, H A Scheraga
Review

Conformational analysis of thyrotropin releasing factor

A W Burgess et al. Proc Natl Acad Sci U S A. 1973 May.

Abstract

Conformational energy calculations on thyrotropin releasing factor and on several of its analogues indicate that the central histidyl residue of the native molecule is in an extended conformation. Some derivatives (with a reduced biological activity) have an altered conformation. Since some substitutions leave the conformation unchanged but alter the biological activity, these substitutions must involve the sites responsible for binding of the hormone to its receptor.

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References

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