Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 1973 Sep;52(9):2185-90.
doi: 10.1172/JCI107403.

Defective mononuclear phagocyte function in patients with myelomonocytic leukemia and in some patients with lymphoma

M J Cline

Defective mononuclear phagocyte function in patients with myelomonocytic leukemia and in some patients with lymphoma

M J Cline. J Clin Invest. 1973 Sep.

Abstract

Mononuclear phagocytes from 8 of 10 patients with myelomonocytic leukemia and 2 of 9 patients with lymphoma phagocytized several species of bacteria but did not inhibit intracellular bacterial replication normally. Intracellular organisms were protected from the lethal effects of antibiotics in the medium. This defect of microbicidal function of malignant monocytes may explain in part the frequency of infection and the mechanism of antibiotic-resistant infection in some patients with malignant myeloproliferative and lymphoproliferative diseases.

PubMed Disclaimer

References

    1. J Immunol. 1964 Jan;92:145-54 - PubMed
    1. J Clin Invest. 1969 Aug;48(8):1478-88 - PubMed
    1. J Lab Clin Med. 1973 Feb;81(2):311-6 - PubMed
    1. Blood. 1972 Jul;40(1):31-41 - PubMed
    1. Blood. 1973 Jan;41(1):45-57 - PubMed

MeSH terms