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Clinical Trial
. 1973 Aug 18;3(5876):379-81.
doi: 10.1136/bmj.3.5876.379.

Trial of chloramphenicol for meningitis in northern savanna of Africa

H C Whittle, N M Davidson, B M Greenwood, D A Warrell, A Tomkins, P Tugwell, A Zalin, A D Bryceson, E H Parry, M Brueton, M Duggan, A D Rajković
Clinical Trial

Trial of chloramphenicol for meningitis in northern savanna of Africa

H C Whittle et al. Br Med J. .

Abstract

In a controlled trial chloramphenicol proved as effective and much cheaper than penicillin for the treatment of group A meningococcal meningitis in Zaria, Nigeria. A short course of five days cured most patients. Adults and older children were soon able to take chloramphenicol by mouth, which reduced the cost and simplified treatment.It is suggested that chloramphenicol is a suitable alternative to sulphonamides for the treatment of meningococcal meningitis in those parts of Africa where the organism is sulphonamide-resistant.

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