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. 1973 Aug;12(2):405-7.
doi: 10.1128/JVI.12.2.405-407.1973.

Effect of nalidixic acid on PBS2 bacteriophage infection of Bacillus subtilis

A R Price, S M Fogt

Effect of nalidixic acid on PBS2 bacteriophage infection of Bacillus subtilis

A R Price et al. J Virol. 1973 Aug.

Abstract

Infection of Bacillus subtilis by PBS2 phage, whose DNA contains uracil instead of thymine, is relatively unaffected by low concentrations of nalidixic acid which severely inhibit B. subtilis DNA synthesis. High concentrations of nalidixic acid do inhibit PBS2 DNA synthesis, but more severely reduce the burst size of PBS2 infections. Hydroxyurea blocks PBS2 DNA synthesis, preventing progeny phage production.

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