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. 1973 Dec 14;182(4117):1136-8.
doi: 10.1126/science.182.4117.1136.

Direct evidence for a colchicine-induced impairment in the mobility of membrane components

F Wunderlich, R Müller, V Speth

Direct evidence for a colchicine-induced impairment in the mobility of membrane components

F Wunderlich et al. Science. .

Abstract

Freeze-etch electron microscopy was used to show that colchicine interacts with membranes of the ciliate protozoan Tetrahymena pyriformis. Colchicine impairs the temperature-induced translational and vertical mobility of the membrane-intercalating particles of the freeze-fractured alveolar membranes lying just below the plasma membranes.

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