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Comparative Study
. 1979 Jan 26;561(1):10-6.
doi: 10.1016/0005-2787(79)90485-4.

Detection and characterization of DNA polymerase from Trypanosoma brucei

D K Dube, R O Williams, G Seal, S C Williams
Comparative Study

Detection and characterization of DNA polymerase from Trypanosoma brucei

D K Dube et al. Biochim Biophys Acta. .

Abstract

The predominant DNA polymerase activity has been isolated from the parasitic flagellated protozoan, Trypanosoma brucei. Like mammalian DNA polymerase-alpha the trypanosome DNA polymerase is of large molecular weight (S, 6--8), is resistant to thermal denaturation, is sensitive to N-ethylmaleimide, and is inhibited by high ionic strength. However, specific antisera that cross-react with mammalian DNA polymerase-alpha from different species fail to cross-react with the trypanosome polymerase.

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